5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester

Base Information

• Chemical Name: 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester
• CAS No.: 223449-25-0
• Molecular Formula: C₁₄H₂₂O₈P₂
• Molecular Weight: 380.271
• Mol file: 223449-25-0.mol

Synonyms:5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester

Chemical Property of 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester

There total 7 articles about 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 3,5-bis(bromomethyl)benzoate (29333-41-3) + phosphorous acid trimethyl ester (121-45-9) → 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester (223449-25-0)

Guidance literature:

at 90 ℃;

DOI:10.1016/j.tetlet.2015.11.035

Reference yield: 40.0%

3,5-bis(bromomethyl)benzoic acid (94111-75-8) + phosphorous acid trimethyl ester (121-45-9) → 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester (223449-25-0) + 5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester (223449-19-2)

Guidance literature:

for 16h; Heating;

DOI:10.1016/S0040-4020(99)00062-9

Reference yield: 35.0%

methyl 3,5-dimethylbenzoate (25081-39-4) + phosphorous acid trimethyl ester (121-45-9) → 5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester (223449-25-0)

Guidance literature:

methyl 3,5-dimethylbenzoate; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h; Heating;

phosphorous acid trimethyl ester; Further stages.; Heating;

DOI:10.1021/jo0156161

upstream raw materials:

3,5-bis(bromomethyl)benzoic acid

phosphorous acid trimethyl ester

methyl 3,5-dimethylbenzoate

1,3,5-tris-(methoxycarbonyl)benzene

Downstream raw materials:

[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

3,5-bis-(dimethoxyphosphorylmethyl)benzoic acid diethoxyphosphorylmethylamide

5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester