S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide

Base Information

• Chemical Name: S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide
• CAS No.: 1147096-72-7
• Molecular Formula: C₂₃H₁₉BrCl₂N₄O₄S
• Molecular Weight: 598.304
• Mol file: 1147096-72-7.mol

Synonyms:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide

Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide

There total 3 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-N-acetyl sulfoximide (1147096-71-6) → S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide (1147096-72-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 25 - 30 ℃; for 3h;

Reference yield:

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide (1147096-26-1) → S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide (1147096-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 3 h / 5 - 30 °C / Inert atmosphere

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 25 - 30 °C

With pyridine; carbon tetrabromide; triphenylphosphine; In dichloromethane;

Reference yield:

2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide (1147096-70-5) → S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide (1147096-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 3 h / -70 - 30 °C / Inert atmosphere

2: pyridine / dichloromethane / 3 h / 5 - 30 °C / Inert atmosphere

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 25 - 30 °C

With pyridine; carbon tetrabromide; boron tribromide; triphenylphosphine; In dichloromethane;

upstream raw materials:

2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-N-acetyl sulfoximide

Downstream raw materials:

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-{(2-diethylamino)ethyl}sulfoximide