2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

Base Information

• Chemical Name: 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide
• CAS No.: 1147096-70-5
• Molecular Formula: C₃₀H₂₆Cl₂N₄O₆S
• Molecular Weight: 641.532
• Mol file: 1147096-70-5.mol

Synonyms:2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

Chemical Property of 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

There total 9 articles about 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

→ 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide (1147096-70-5)

Guidance literature:

Reference yield:

C18H18ClNO5S + 2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide (229343-30-0) → 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide (1147096-70-5)

Guidance literature:

In tetrahydrofuran; at 10 - 30 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

5-chloro-2-nitrobenzoic acid (2516-95-2) → 2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide (1147096-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; trichlorophosphate / acetonitrile / 1 h / 0 - 30 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 25 - 30 °C

3: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

With pyridine; tin(II) chloride dihdyrate; trichlorophosphate; In tetrahydrofuran; ethyl acetate; acetonitrile;

DOI:10.1016/j.ejmech.2012.10.005

upstream raw materials:

methyl 4-((2-methoxyethyl)sulfinyl)benzoate

5-chloro-2-nitrobenzoic acid

2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide

methyl 4-(2-methoxyethylsulfonimidoyl)benzoate hydrochloride

Downstream raw materials:

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-{(2-diethylamino)ethyl}sulfoximide

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-bromoethyl)-N-acetyl sulfoximide

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-N-acetyl sulfoximide

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide