S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

Base Information

Chemical Name:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide
CAS No.:1147096-26-1
Molecular Formula:C₂₁H₁₈Cl₂N₄O₄S
Molecular Weight:493.37
Hs Code.:

Synonyms:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

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Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

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Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

There total 10 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1147096-70-5
2-(4-(N-benzyloxycarbonyl-2-methoxyethylsulfonimidoyl)benzamido)-5-chloro-N-(5-chloropyridin-2-yl)benzamide

: 1147096-26-1
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

Guidance literature:: With boron tribromide; In dichloromethane; at -70 - 30 ℃; for 3h; Inert atmosphere;

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1147096-26-1
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; trichlorophosphate / acetonitrile / 1 h / 0 - 30 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethyl acetate / 2 h / 25 - 30 °C

3: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 3 h / 25 - 30 °C / Inert atmosphere

With pyridine; tin(II) chloride dihdyrate; boron tribromide; trichlorophosphate; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2012.10.005

Reference yield:

: 1416698-92-4
methyl 4-(2-methoxyethylsulfonimidoyl)benzoate hydrochloride

: 1147096-26-1
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-(2-hydroxyethyl)-sulfoximide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

2: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

4: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 3 h / 25 - 30 °C / Inert atmosphere

With pyridine; oxalyl dichloride; water; boron tribromide; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.10.005