methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

Base Information

Chemical Name:methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate
CAS No.:928783-11-3
Molecular Formula:C₂₀H₁₅Cl₂F₃N₂O₄
Molecular Weight:475.251
Hs Code.:

Synonyms:methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

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Chemical Property of methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

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Technology Process of methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

There total 7 articles about methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 928783-11-3
methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

3.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

3.2: 1.5 h / 80 °C

4.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

5.1: dichloromethane / 6 h / Heating / reflux

5.2: 15 h / 20 °C

With ammonia; sodium acetate; potassium carbonate; potassium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 67-56-1
methanol

: 864730-52-9
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid amide

: 928783-11-3
methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

Guidance literature:: 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoic acid amide; In dichloromethane; for 6h; Heating / reflux;

methanol; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 928783-11-3
methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl] carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

2.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

2.2: 1.5 h / 80 °C

3.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

4.1: dichloromethane / 6 h / Heating / reflux

4.2: 15 h / 20 °C

With ammonia; sodium acetate; potassium hydrogencarbonate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;