(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

Base Information

Chemical Name:(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide
CAS No.:1353547-78-0
Molecular Formula:C₂₂H₂₈N₂O₇S
Molecular Weight:464.54
Hs Code.:

Synonyms:(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

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Chemical Property of (E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

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Technology Process of (E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

There total 10 articles about (E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1353547-74-6
(E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

: 75-03-6
ethyl iodide

: 1353547-78-0
(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

Guidance literature:: (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.75h;

ethyl iodide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 23056-40-8
2-chloro-5-methyl-3-nitro-pyridine

: 1353547-78-0
(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium / 4 h / Reflux; Inert atmosphere

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 48 h / Inert atmosphere; Reflux

3.1: sodium carbonate / methanol / 1 h / 20 °C

4.1: dihydrogen peroxide; acetic acid / 6 h / 60 °C

5.1: water; sodium carbonate / methanol / 4 h / 20 °C

5.2: pH 2

6.1: piperidine; pyridine / 3 h / Inert atmosphere; Reflux

7.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

8.1: pyridine / 20 °C / Cooling with ice

9.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C

9.2: 2 h / 20 °C

With piperidine; pyridine; N-Bromosuccinimide; water; dihydrogen peroxide; sodium; iron; sodium hydride; sodium carbonate; acetic acid; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane;

Reference yield:

: 1353547-72-4
(E)-2-methoxy-3-nitro-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine

: 1353547-78-0
(E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; iron / methanol / 2 h / 50 °C / Inert atmosphere

2.1: pyridine / 20 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C

3.2: 2 h / 20 °C

With pyridine; iron; sodium hydride; acetic acid; In tetrahydrofuran; methanol;