Methyl 3-chloropicolinate

Base Information

• Chemical Name: Methyl 3-chloropicolinate
• CAS No.: 116383-98-3
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• Mol file: 116383-98-3.mol

Synonyms:Methyl 3-chloropicolinate;methyl 3-chloropyridine-2-carboxylate;

Chemical Property of Methyl 3-chloropicolinate

Chemical Property:

• Vapor Pressure: 0.018mmHg at 25°C
• Melting Point: 47-54 ºC
• Refractive Index: 1.531
• Boiling Point: 254°Cat760mmHg
• PKA: -0.91±0.10(Predicted)
• Flash Point: 107.4°C
• PSA: 39.19000
• Density: 1.294g/cm³
• LogP: 1.52160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

Methyl3-chloropicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-chloropicolinate

There total 1 articles about Methyl 3-chloropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-pyridine (2402-77-9) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 3-Chloropyridine (626-60-8) + 3-chloro-2-(methoxycarbonyl)pyridine (116383-98-3)

Guidance literature:

With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; at 110 ℃; for 23h; under 37503 Torr;

DOI:10.1016/S0040-4039(99)00597-3

Reference yield:

3-chloro-2-(methoxycarbonyl)pyridine (116383-98-3) → N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-3-(thieno[3,2-b]pyridin-3-yloxy)azetidine-1-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: sodium t-butanolate / N,N-dimethyl-formamide / 65 °C

2: caesium carbonate / N,N-dimethyl-formamide / 110 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; caesium carbonate; sodium t-butanolate; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

2,3-dichloro-pyridine

methanol

carbon monoxide

Refernces