cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

Base Information

Chemical Name:cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate
CAS No.:1345971-32-5
Molecular Formula:C₂₂H₁₉ClF₆O₃
Molecular Weight:480.834
Hs Code.:

Synonyms:cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

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Chemical Property of cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

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Technology Process of cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

There total 3 articles about cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1345971-11-0
cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-oxoacetate

: 1679-18-1
4-Chlorophenylboronic acid

: 1345971-32-5
cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

Guidance literature:: With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (S)-2,4-bis(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-5,5-dimethyl-hexa-2,3-diene; In water; isopropyl alcohol; at 20 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja207748r

Reference yield:

: 54166-92-6
oxalic acid-chloride cyclohexyl ester

: 1345971-32-5
cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -50 - 20 °C / Inert atmosphere

2: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (S)-2,4-bis(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-5,5-dimethyl-hexa-2,3-diene / water; isopropyl alcohol / 6 h / 20 °C / Inert atmosphere

With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (S)-2,4-bis(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-5,5-dimethyl-hexa-2,3-diene; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/ja207748r

Reference yield:

: 108-93-0
cyclohexanol

: 1345971-32-5
cyclohexyl 2-(3,5-bistrifluoromethylphenyl)-2-(4-chlorophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 4.25 h / 0 °C

1.2: 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / -50 - 20 °C / Inert atmosphere

3.1: potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (S)-2,4-bis(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-5,5-dimethyl-hexa-2,3-diene / water; isopropyl alcohol / 6 h / 20 °C / Inert atmosphere

With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; (S)-2,4-bis(2-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)phenyl)-5,5-dimethyl-hexa-2,3-diene; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/ja207748r