(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

Base Information

Chemical Name:(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol
CAS No.:1352743-35-1
Molecular Formula:C₂₀H₂₉NO₃Si
Molecular Weight:359.541
Hs Code.:

Synonyms:(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

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Chemical Property of (R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

Chemical Property:

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Technology Process of (R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

There total 8 articles about (R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1352743-34-0
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methyl acetate

: 1352743-35-1
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 6h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1352743-35-1
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

4: 2 h / 90 °C

5: potassium carbonate / methanol / 6 h / 20 °C

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 4: Boekelheide rearrangement;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-15-7
(R)-2-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4(1H)-one

: 1352743-35-1
(R)-{6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypyridin-2-yl}methanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

3: 2 h / 90 °C

4: potassium carbonate / methanol / 6 h / 20 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; 3: Boekelheide rearrangement;
DOI:10.1002/ejoc.201100681