3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

Base Information

Chemical Name:3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide
CAS No.:1201662-21-6
Molecular Formula:C₂₇H₂₂Cl₂FNO₄S
Molecular Weight:546.446
Hs Code.:

Synonyms:3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

Chemical Property:

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Technology Process of 3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

There total 7 articles about 3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201662-19-2
N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

: 1201662-21-6
3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1201662-21-6
3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane; isopropyl alcohol / 1 h / 20 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

3.2: 0 °C / pH 3 - 4

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

4.2: 1 h / 20 °C

5.1: tetrahydrofuran; diethyl ether / 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; isopropyl alcohol;

Reference yield:

: 918402-06-9
methyl 4-((4-fluorobenzylamino)methyl)benzoate

: 1201662-21-6
3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxy-N-(4-(hydroxy(phenyl)methyl)benzyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

2.2: 0 °C / pH 3 - 4

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

3.2: 1 h / 20 °C

4.1: tetrahydrofuran; diethyl ether / 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;