(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

Base Information

Chemical Name:(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane
CAS No.:311820-19-6
Molecular Formula:C₁₈H₁₇BF₃OP
Molecular Weight:348.112
Hs Code.:

Synonyms:(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

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Chemical Property of (R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

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Technology Process of (R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

There total 1 articles about (R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 67-56-1
methanol

: (S(P),1R,2S)-(+)-N-Methyl-N-((1-hydroxy-1-phenyl)prop-2-yl)-P-(4-(trifluoromethyl)phenyl)-P-(1-naphthyl)phosphinamide-Borane

: 311820-19-6
(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

Guidance literature:: With sulfuric acid; In methanol; (Ar); standard Schlenk technique; soln. of amide-borane in methanol cooled on ice; concd. sulfuric acid added dropwise; stirred at room temp. for 15 h; mixt. concd.; chromd. (SiO2, hexane/ethyl acetate, 95/5); elem. anal.;
DOI:10.1021/om0004489

Reference yield: 70.0%

: 311820-19-6
(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

: 311820-10-7
(S)-(+)-Methyl (1'-Bromo-1-ferrocenyl)-phenylphosphinite-Borane

: 311820-13-0
(S,S)-(+)-1-[(1-naphthyl)(4-methoxyphenyl)phosphino]-1'-[(1-naphthyl)((4-trifluoromethyl)phenyl)phosphino]ferrocene

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; diethyl ether; (Ar); standard Schlenk technique; Fe compd. dissolved in Et2O and THF; cooled to -70°C; sec-BuLi added after 1 h; soln. of methyl phosphinite-borane in THF transferred; mixt. warmed to ambient temp. for 15 h; H2O added; extd. (CH2Cl2); dried (MgSO4); filtered; concd.; chromd. (SiO2, CH2Cl2/hexane, 1/2); chromd. (alumina, CH2Cl2/hexane, 1/1); elem. anal.;
DOI:10.1021/om0004489

Reference yield:

: 33272-09-2
1,1'-dilithioferrocene

: 311820-19-6
(R)-(-)-Methyl (1-Naphthyl)(4-(trifluoromethyl)phenyl)phosphinite-Borane

: 311820-21-0
[(C₅H₄(C₁₀H₇)P(C₆H₄CF₃)(BH₃))2Fe]

Guidance literature:: In tetrahydrofuran; diethyl ether; (Ar); standard Schlenk technique; suspn. of Fe complex in Et2O/THF added to soln. of methyl phosphinite-borane in THF at -50°C; mixt. warmed to room temp. for 15 h; H2O added; solvent removed in vac.; extd. (CH2Cl2); dried (MgSO4); filtered; evapd.; chromd.; concd.;
DOI:10.1021/om0004489