C₂₀H₁₉N₅O₃

Base Information

Chemical Name:C₂₀H₁₉N₅O₃
CAS No.:1450754-50-3
Molecular Formula:C₂₀H₁₉N₅O₃
Molecular Weight:377.403
Hs Code.:

C<sub>20</sub>H<sub>19</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:C₂₀H₁₉N₅O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₀H₁₉N₅O₃

Chemical Property:

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Technology Process of C₂₀H₁₉N₅O₃

There total 6 articles about C₂₀H₁₉N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-30-5
succinic acid anhydride

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 1450754-50-3
C₂₀H₁₉N₅O₃

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201300683

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1450754-50-3
C₂₀H₁₉N₅O₃

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 12 h / Inert atmosphere; Reflux

2: guanidine hydrochloride; sodium hydroxide / isopropyl alcohol / 18 h / Inert atmosphere; Reflux

3: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere

4: palladium on activated charcoal; hydrogen / ethyl acetate / Inert atmosphere

5: dmap / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; palladium on activated charcoal; hydrogen; guanidine hydrochloride; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/anie.201300683

Reference yield:

: 55314-16-4,75415-01-9,123367-26-0
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

: 1450754-50-3
C₂₀H₁₉N₅O₃

Guidance literature:: Multi-step reaction with 4 steps

1: guanidine hydrochloride; sodium hydroxide / isopropyl alcohol / 18 h / Inert atmosphere; Reflux

2: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / ethyl acetate / Inert atmosphere

4: dmap / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; palladium on activated charcoal; hydrogen; guanidine hydrochloride; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/anie.201300683