6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

Base Information

Chemical Name:6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester
CAS No.:1268239-60-6
Molecular Formula:C₁₉H₂₄N₂O₆
Molecular Weight:376.409
Hs Code.:

Synonyms:6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

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Chemical Property of 6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

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Technology Process of 6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

There total 5 articles about 6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1124174-16-8
methyl 2-((1r,4r)-4-hydroxycyclohexyl)acetate

: 174648-98-7
6-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1268239-60-6
6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

Guidance literature:: bis(trichloromethyl) carbonate; methyl 2-((1r,4r)-4-hydroxycyclohexyl)acetate; With pyridine; In dichloromethane; at 0 - 20 ℃;

6-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1268239-60-6
6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 19 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C

3.1: hydrogenchloride / water; acetone / 15 h / 20 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

5.1: pyridine / dichloromethane / 0 - 20 °C

5.2: 3.5 h / 20 °C

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; hydrogen; sodium hydride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 172270-85-8
8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane

: 1268239-60-6
6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C

2.1: hydrogenchloride / water; acetone / 15 h / 20 °C

3.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

4.1: pyridine / dichloromethane / 0 - 20 °C

4.2: 3.5 h / 20 °C

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane; water; acetone;