2-Morpholinonicotinaldehyde

Base Information

• Chemical Name: 2-Morpholinonicotinaldehyde
• CAS No.: 465514-09-4
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID60380193
• Wikidata: Q72493019
• Mol file: 465514-09-4.mol

Synonyms:2-Morpholinonicotinaldehyde;465514-09-4;2-morpholin-4-ylpyridine-3-carbaldehyde;2-Morpholin-4-ylpyridine-3-carboxaldehyde;2-MORPHOLIN-4-YL-PYRIDINE-3-CARBALDEHYDE;2-morpholin-4-ylnicotinaldehyde;2-(morpholin-4-yl)pyridine-3-carbaldehyde;2-Morpholinopyridine-3-carboxaldehyde;SCHEMBL101958;DTXSID60380193;CCPVZIBHRFCNTR-UHFFFAOYSA-N;MFCD03086195;AKOS005070067;2-morpholinonicotinaldehyde, AldrichCPR;BP-10861;FT-0613110;VU0549443-1;EN300-234939;F18144;1Y-0719;J-510132;F9995-1195

Chemical Property of 2-Morpholinonicotinaldehyde

Chemical Property:

• Vapor Pressure: 1.06E-05mmHg at 25°C
• Melting Point: 54 ºC
• Refractive Index: 1.586
• Boiling Point: 371 ºC at 760 mmHg
• Flash Point: 178.2 ºC
• PSA: 42.43000
• Density: 1.219 g/cm³
• LogP: 0.79570
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.089877630
• Heavy Atom Count: 14
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

2-Morpholinonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=C(C=CC=N2)C=O

Technology Process of 2-Morpholinonicotinaldehyde

There total 2 articles about 2-Morpholinonicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-fluoropyridine-3-carboxaldehyde (36404-90-7) → 2-morpholinonicotinaldehyde (465514-09-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 15h;

DOI:10.1039/d0gc01256d

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-chloro-3-carbaldehydepyridine (36404-88-3) → 2-morpholinonicotinaldehyde (465514-09-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

Reference yield: 86.0%

2-morpholinonicotinaldehyde (465514-09-4) + 4-methoxybenzoic acid hydrazide (3290-99-1) → (E)-4-methoxy-N'-((2-morpholinopyridin-3-yl)methylene)benzohydrazide

Guidance literature:

With acetic acid; In ethanol; at 20 ℃;

upstream raw materials:

morpholine

2-fluoropyridine-3-carboxaldehyde

2-chloro-3-carbaldehydepyridine