3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Base Information

Chemical Name:3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile
CAS No.:1416324-57-6
Molecular Formula:C₃₂H₃₄N₄O₆
Molecular Weight:570.645
Hs Code.:

Synonyms:3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

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Chemical Property of 3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

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Technology Process of 3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

There total 7 articles about 3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1416324-57-6
3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

5.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

6.1: potassium carbonate / acetonitrile / 15 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; nickel (II) chloride hexahydrate; sodium hexamethyldisilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416324-51-0
methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-57-6
3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4.1: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

5.1: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

6.1: potassium carbonate / acetonitrile / 15 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; nickel (II) chloride hexahydrate; sodium hexamethyldisilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-57-6
3-(((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

4: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

5: potassium carbonate / acetonitrile / 15 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; nickel (II) chloride hexahydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;