2-Hydroxy-4-(trifluoromethyl)pyridine

Base Information

Chemical Name:2-Hydroxy-4-(trifluoromethyl)pyridine
CAS No.:50650-59-4
Molecular Formula:C6H4F3NO
Molecular Weight:163.099
Hs Code.:29333990
European Community (EC) Number:610-554-0
DSSTox Substance ID:DTXSID20379402
Wikidata:Q72482062
ChEMBL ID:CHEMBL2323845
Mol file:50650-59-4.mol

Synonyms:2-Hydroxy-4-(trifluoromethyl)pyridine;50650-59-4;4-(trifluoromethyl)pyridin-2-ol;4-(trifluoromethyl)pyridin-2(1h)-one;4-trifluoromethyl-pyridin-2-ol;4-(trifluoromethyl)-1H-pyridin-2-one;4-(Trifluoromethyl)-2-pyridone;2(1H)-Pyridinone, 4-(trifluoromethyl)-;MFCD00153195;4-Trifluoromethyl-2(1H)pyridinone;Maybridge3_000683;SCHEMBL1660106;CHEMBL2323845;4-(Trifluoromethyl)-2-pyridinol;DTXSID20379402;4-(Trifluoromethyl)-2-pyridinone;4-(Trifluoromethyl)pyridine-2-ol;IKHLLNMSMFVTLP-UHFFFAOYSA-M;VODLFQBLXUIESC-UHFFFAOYSA-N;4-(trifluoromethyl) pyridin-2-ol;HMS1432P01;4-trifluoromethylpyridine-2(1h)-one;BBL101318;CCG-50732;CL0199;MFCD09029339;STL555114;AKOS005063407;AKOS015961757;AB04095;CS-W003573;FS-1455;2-hydroxy-4-(trifluoromethyl)-pyridine;IDI1_012070;AC-23240;AM803972;CS-10708;SY024702;4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE;2-Hydroxy-4-(trifluoromethyl)pyridine, 97%;A7512;FT-0639923;T2790;EN300-84905;4-(trifluoromethyl)-1,2-dihydropyridin-2-one;Q-101240;Q-101472;SR-01000640086-1;Z1741962504;4-(Trifluoromethyl)pyridin-2(1H)-one

Suppliers and Price of 2-Hydroxy-4-(trifluoromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Trifluoromethylpyridin-2-ol
10g
$ 1320.00

TCI Chemical
4-(Trifluoromethyl)-2-pyridone >98.0%(GC)
5g
$ 246.00

TCI Chemical
4-(Trifluoromethyl)-2-pyridone >98.0%(GC)
1g
$ 76.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)pyridine 98%
250 mg
$ 16.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)pyridine 98%
1 g
$ 24.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)pyridine 98%
5 g
$ 95.00

Sigma-Aldrich
2-Hydroxy-4-(trifluoromethyl)pyridine 97%
250mg
$ 167.00

Medical Isotopes, Inc.
4-Trifluoromethylpyridin-2-ol
10 g
$ 2200.00

Matrix Scientific
2-Hydroxy-4-(trifluoromethyl)pyridine 98%
500mg
$ 23.00

Matrix Scientific
2-Hydroxy-4-(trifluoromethyl)pyridine 98%
1g
$ 35.00

Total 98 raw suppliers

Chemical Property of 2-Hydroxy-4-(trifluoromethyl)pyridine

Chemical Property:

Vapor Pressure:0.108mmHg at 25°C
Melting Point:161-165 ºC
Refractive Index:1.436
Boiling Point:221.2 °C at 760 mmHg
PKA:10.76±0.10(Predicted)
Flash Point:87.6 °C
PSA：33.12000
Density:1.398 g/cm³
LogP:1.80600
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:Soluble in methanol.
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:163.02449824
Heavy Atom Count:11
Complexity:239

Purity/Quality:

99% ^*data from raw suppliers

4-Trifluoromethylpyridin-2-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 22-37/38-41
Safety Statements: 26-36-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CNC(=O)C=C1C(F)(F)F
Uses 2-Hydroxy-4-(trifluoromethyl)pyridine is used in the production of agrochemicals and pharmaceuticals.

Technology Process of 2-Hydroxy-4-(trifluoromethyl)pyridine

There total 11 articles about 2-Hydroxy-4-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 22282-72-0
2-oxo-1,2-dihydropyridine-4-carboxylic acid

: 50650-59-4
4-(trifluoromethyl)-2-pyridone

Guidance literature:: With sulfur tetrafluoride; hydrogen fluoride; at 85 ℃; for 24h; Autoclave; Inert atmosphere;
DOI:10.1021/acs.joc.9b03011

Reference yield: 74.0%

: 75-77-4
chloro-trimethyl-silane

: 59938-06-6,17129-06-5
4-ethoxy-1,1,1-trifluoro-3-butene-2-one

: 107-14-2
chloroacetonitrile

: 50650-59-4
4-(trifluoromethyl)-2-pyridone

Guidance literature:: chloro-trimethyl-silane; With zinc; In tetrahydrofuran; for 0.5h; Inert atmosphere;

4-ethoxy-1,1,1-trifluoro-3-butene-2-one; chloroacetonitrile; In tetrahydrofuran; at 20 - 40 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; for 1h; Reflux; Inert atmosphere;
DOI:10.1021/op000109r

Reference yield: 74.0%

: 59938-06-6
(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

: 107-14-2
chloroacetonitrile

: 50650-59-4
4-(trifluoromethyl)-2-pyridone

Guidance literature:: (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one; chloroacetonitrile; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 2h; Heating;

With hydrogenchloride; In tetrahydrofuran; for 1h; Heating;
DOI:10.1016/S0968-0896(01)00070-0