(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

Base Information

Chemical Name:(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate
CAS No.:1403660-65-0
Molecular Formula:C₂₄H₃₈O₅
Molecular Weight:406.563
Hs Code.:

Synonyms:(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

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Chemical Property of (2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

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Technology Process of (2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

There total 3 articles about (2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 3282-30-2
pivaloyl chloride

: 477781-63-8
(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentan-1-ol

: 1403660-65-0
(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo3016709

Reference yield:

: 238757-51-2
(1S,5R,6S,7S,8S)-7-Benzyloxy-6,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-3-one

: 1403660-65-0
(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

2: camphor-10-sulfonic acid / dichloromethane / 12 h / 0 - 20 °C

3: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo3016709

Reference yield:

: 477781-62-7
(3R,4S,5R,6R)-5-(benzyloxy)-4,6-dimethylheptane-1,3,7-triol

: 1403660-65-0
(2R,3R,4S)-3-(benzyloxy)-4-((R)-2,2-dimethyl-1,3-dioxan-4-yl)-2-methylpentyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / dichloromethane / 12 h / 0 - 20 °C

2: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With dmap; camphor-10-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/jo3016709