2,6-Dimethoxypyridine-3-carboxylic acid

Base Information

• Chemical Name: 2,6-Dimethoxypyridine-3-carboxylic acid
• CAS No.: 16727-43-8
• Molecular Formula: C8H9NO4
• Molecular Weight: 183.164
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10357411
• Nikkaji Number: J1.814.788B
• Wikidata: Q72468501
• ChEMBL ID: CHEMBL1388059
• Mol file: 16727-43-8.mol

Synonyms:2,6-Dimethoxypyridine-3-carboxylic acid;16727-43-8;2,6-Dimethoxynicotinic acid;3-PYRIDINECARBOXYLIC ACID, 2,6-DIMETHOXY-;2,6-Dimethoxy-nicotinic acid;2,6-Dimethoxynicotinicacid;Oprea1_518070;MLS000779169;SCHEMBL198490;CHEMBL1388059;DTXSID10357411;HMS2744D19;BCP27216;BBL028153;MFCD00075582;STK503770;AKOS005171603;AB02889;AC-5159;SMR000415865;TS-00217;AM20050865;BB 0260371;FT-0657516;2,6-Dimethoxypyridine-3-carboxylic acid, 99%;EN300-381198;J-010351;Z1255415671

Chemical Property of 2,6-Dimethoxypyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.000805mmHg at 25°C
• Melting Point: 140-144 °C(lit.)
• Refractive Index: 1.535
• Boiling Point: 293.067 °C at 760 mmHg
• PKA: 3.63±0.10(Predicted)
• Flash Point: 131.043 °C
• PSA: 68.65000
• Density: 1.279 g/cm³
• LogP: 0.79700
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 183.05315777
• Heavy Atom Count: 13
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dimethoxypyridine-3-carboxylic acid 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)C(=O)O)OC
• Uses: 2,6-Dimethoxypyridine-3-carboxylic acid (2,6-dimethoxynicotinic acid, DMPH) may be used in the preparation of novel benzothiazolo naphthyridone carboxylic acid derivatives. It may be used in the preparation of following complexes, via reaction with different precursors [Ti(η5-C5H5)2Cl2], [Ti(η5-C5H4Me)2Cl2], [Ti(η5-C5H4SiMe3)(η5-C5H5)Cl2], [Ti(η5-C5Me5)Cl3], SnMe3Cl and GatBu3:[Ti(η5-C5H5)2(DMP-κO)2][Ti(η5-C5H4Me)2(DMP-κO)2] [Ti(η5-C5H4SiMe3)(η5-C5H5)(DMP-κO)2[Ti(η5-C5Me5)(DMP-κ2O,O′)3] [SnMe3(μ-DMP-κO:κO′)]∞[GatBu2(μ-DMP-κO:κO′)]2

Technology Process of 2,6-Dimethoxypyridine-3-carboxylic acid

There total 1 articles about 2,6-Dimethoxypyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2,6-dichloropyridine-3-carboxylic acid (38496-18-3) → 6-chloro-2-methoxypyridine-3-carboxylic acid (65515-33-5) + 2,6-dimethoxynicotinic acid (16727-43-8) + 2-chloro-6-methoxypyridine-3-carboxylic acid (503000-87-1)

Guidance literature:

With potassium tert-butylate; at 60 ℃; for 1h; regioselective reaction; Microwave irradiation;

DOI:10.1055/s-0030-1259283

Reference yield: 87.0%

1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol (1276594-32-1) + 2,6-dimethoxynicotinic acid (16727-43-8) → 1-(benzyloxy)-4-bromo-3,3,4,4-tetrafluorobutan-2-yl 2,6-dimethoxynicotinate (1224874-14-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b922442d

Reference yield: 82.0%

2,6-dimethoxynicotinic acid (16727-43-8) + triphenyltin chloride (639-58-7) → C26H23NO4Sn (1412439-85-0)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 0.583333h; Inert atmosphere;

DOI:10.2174/157018012802652976

upstream raw materials:

methanol

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

2,6-dimethoxynicotinoyl chloride

2,6-dimethoxynicotinic acid ethyl ester

N-benzyl-2-cyclohexyl-2-[2-(2,6-dimethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-yl]-acetamide

1-(benzyloxy)-4-bromo-3,3,4,4-tetrafluorobutan-2-yl 2,6-dimethoxynicotinate