C₃₇H₄₄F₂N₈O₅

Base Information

• Chemical Name: C₃₇H₄₄F₂N₈O₅
• CAS No.: 1350560-57-4
• Molecular Formula: C₃₇H₄₄F₂N₈O₅
• Molecular Weight: 718.804
• Mol file: 1350560-57-4.mol

Synonyms:C₃₇H₄₄F₂N₈O₅

Chemical Property of C₃₇H₄₄F₂N₈O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₄F₂N₈O₅

There total 15 articles about C₃₇H₄₄F₂N₈O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

dichloromethane (75-09-2) + C6H14N2O2 (1350466-83-9) + C30H32F2N6O2 (184378-04-9) + 1,1'-carbonyldiimidazole (530-62-1) → C37H44F2N8O5 (1350560-57-4)

Guidance literature:

dichloromethane; C₃₀H₃₂F₂N₆O₂; 1,1'-carbonyldiimidazole; at -10 ℃; for 2h; Inert atmosphere;

C₆H₁₄N₂O₂; at -10 - 30 ℃; for 3h; Inert atmosphere;

Reference yield:

C12H19N3O2 → C37H44F2N8O5 (1350560-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / 5%-palladium/activated carbon / tert-butyl methyl ether; methanol / 1.5 h / 20 - 25 °C / 760.05 Torr

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / -10 °C / Inert atmosphere

2.2: 22 h / 0 - 30 °C

With hydrogen; 1,1'-carbonyldiimidazole; 5%-palladium/activated carbon; In methanol; dichloromethane; tert-butyl methyl ether;

Reference yield:

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → C37H44F2N8O5 (1350560-57-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: magnesium / tert-butyl methyl ether / 4 h / 55 °C

1.2: -10 - 0 °C

1.3: 3 h / 25 - 50 °C

2.1: sodium hydroxide / dimethyl sulfoxide / 5 h / 25 - 30 °C

3.1: water; lithium chloride; sodium tetrahydroborate / isopropyl alcohol / 20 h / -5 - 30 °C

3.2: pH 1

4.1: sodium hydrogencarbonate / toluene / 24 h / -15 °C / Enzymatic reaction

5.1: sodium hydrogencarbonate; iodine / ethyl acetate / 5 h / -15 °C

6.1: dimethyl sulfoxide / 24 h / 25 - 90 °C

6.2: 3 h / 25 - 30 °C

7.1: hydrogenchloride / tert-butyl methyl ether; acetone / 0.5 h / 25 - 30 °C

8.1: triethylamine / dichloromethane / 1 h / 12 - 22 °C

8.2: 4 h / 12 - 25 °C

9.1: 2,6-di-tert-butyl-4-methyl-phenol; sodium hydroxide; water / dimethyl sulfoxide / 0.17 h / 30 °C

9.2: 32 °C

10.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / -10 °C / Inert atmosphere

10.2: 22 h / 0 - 30 °C

With hydrogenchloride; sodium tetrahydroborate; 2,6-di-tert-butyl-4-methyl-phenol; water; iodine; sodium hydrogencarbonate; magnesium; triethylamine; 1,1'-carbonyldiimidazole; lithium chloride; sodium hydroxide; In dichloromethane; tert-butyl methyl ether; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; toluene;

upstream raw materials:

2-chloro-1-(2,4-dichlorophenyl)ethanone

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol

2-methylpropanoic acid [(2S)-4-(2,4-difluorophenyl)-2-hydroxymethyl-4-penten-1-yl] ester

Downstream raw materials:

posaconazote