(Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate

Base Information

• Chemical Name: (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate
• CAS No.: 1393131-24-2
• Molecular Formula: C₃₆H₂₇NO₄S
• Molecular Weight: 569.681
• Mol file: 1393131-24-2.mol

Synonyms:(Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate

Chemical Property of (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate

There total 6 articles about (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide (1393131-07-1) + benzoyl chloride (98-88-4) → (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate (1393131-24-2)

Guidance literature:

With tributylphosphine; triethylamine; In dichloromethane; at 20 ℃; for 8h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c2cc33972b

Reference yield:

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) → (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate (1393131-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 12 h / 80 °C / Inert atmosphere

2: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3: tributylphosphine; triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 3: Wittig reaction;

DOI:10.1039/c2cc33972b

Reference yield:

(2-hydroxymethyl-phenyl)-carbamic acid benzyl ester (111881-64-2) → (Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate (1393131-24-2)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: toluene / 12 h / 80 °C / Inert atmosphere

3: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

4: tributylphosphine; triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene; 4: Wittig reaction;

DOI:10.1039/c2cc33972b

upstream raw materials:

2-Aminobenzyl alcohol

4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide

benzoyl chloride