4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide
• CAS No.: 1195694-52-0
• Molecular Formula: C₂₂H₁₉NO₃S
• Molecular Weight: 377.464
• Mol file: 1195694-52-0.mol

Synonyms:4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

There total 13 articles about 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(2-aminophenyl)-1-phenylprop-2-en-1-one (108714-18-7) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1002/ejoc.201801423

Reference yield: 80.0%

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) + (Benzoylmethylene)triphenylphosphorane (20913-05-7,859-65-4) → 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0)

Guidance literature:

In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c2cc33972b

Reference yield: 65.0%

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) + acetophenone (98-86-2) → 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0) + N-[2-(1,5-dioxo-1,5-diphenylpentan-3-yl)phenyl]-4-methylbenzosulfamide

Guidance literature:

With potassium hydroxide; In ethanol; water; at 40 ℃; for 5h;

DOI:10.1007/s10593-017-2010-3

upstream raw materials:

2-Aminobenzyl alcohol

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

(Benzoylmethylene)triphenylphosphorane

(2-hydroxymethyl-phenyl)-carbamic acid benzyl ester

Downstream raw materials:

(Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate

N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide