N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide

Base Information

• Chemical Name: N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide
• CAS No.: 1393131-07-1
• Molecular Formula: C₂₉H₂₃NO₄S
• Molecular Weight: 481.572
• Mol file: 1393131-07-1.mol

Synonyms:N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide

Chemical Property of N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide

There total 5 articles about N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide (1195694-52-0) + benzoyl chloride (98-88-4) → N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide (1393131-07-1)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c2cc33972b

Reference yield:

(2-hydroxymethyl-phenyl)-carbamic acid benzyl ester (111881-64-2) → N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide (1393131-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: toluene / 12 h / 80 °C / Inert atmosphere

3: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

With dmap; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1039/c2cc33972b

Reference yield:

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) → N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)-N-tosylbenzamide (1393131-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 80 °C / Inert atmosphere

2: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1039/c2cc33972b

upstream raw materials:

2-Aminobenzyl alcohol

4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

benzoyl chloride

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

Downstream raw materials:

(Z)-1-phenyl-2-(2-phenyl-1-tosyl-1H-indol-3-yl)vinyl benzoate