(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester
CAS No.:168292-17-9
Molecular Formula:C₂₁H₂₇NO₅
Molecular Weight:373.449
Hs Code.:

Synonyms:(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

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Chemical Property of (S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

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Technology Process of (S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

There total 7 articles about (S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 67-56-1
methanol

: 168292-16-8
(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetonitrile

: 168292-17-9
(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: With hydrogenchloride; for 4h; Ambient temperature;
DOI:10.1021/jo00125a026

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 168292-17-9
(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 62.2 percent / K₂CO₃, Et₄NI / acetone / 5 h / Heating

2: 98 percent / K₂CO₃ / dimethylformamide / 1.5 h / 100 °C

3: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

4: PCC / CH₂Cl₂ / 2 h / Ambient temperature

5: 1.) CH₂Cl₂, room temperature, 3 h, 2.) MeOH, room temperature, 15 h

6: 91 percent / HCl / 4 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; tetraethylammonium iodide; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00125a026

Reference yield:

: 19520-74-2
3-hydroxy-5-methoxy-benzoic acid methyl ester

: 168292-17-9
(S)-((R)-2-Hydroxy-1-phenyl-ethylamino)-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / K₂CO₃ / dimethylformamide / 1.5 h / 100 °C

2: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: PCC / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) CH₂Cl₂, room temperature, 3 h, 2.) MeOH, room temperature, 15 h

5: 91 percent / HCl / 4 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00125a026