2-Bromo-5-chlorobenzaldehyde

Base Information

• Chemical Name: 2-Bromo-5-chlorobenzaldehyde
• CAS No.: 174265-12-4
• Molecular Formula: C7H4BrClO
• Molecular Weight: 219.465
• Hs Code.: 29130000
• Mol file: 174265-12-4.mol

Synonyms:Benzaldehyde,2-bromo-5-chloro-;5-Chloro-2-bromobenzaldehyde;

Chemical Property of 2-Bromo-5-chlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.014mmHg at 25°C
• Melting Point: 66 °C
• Refractive Index: 1.623
• Boiling Point: 257.7 °C at 760 mmHg
• Flash Point: 109.7 °C
• PSA: 17.07000
• Density: 1.698 g/cm³
• LogP: 2.91500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-chlorobenzaldehyde

There total 12 articles about 2-Bromo-5-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-5-chlorobenzyl alcohol (60666-70-8) → 2-bromo-5-chlorobenzaldehyde (174265-12-4)

Guidance literature:

2-bromo-5-chlorobenzyl alcohol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1039/c7cc09264d

Reference yield: 95.0%

1-bromo-4-chloro-2-dibromomethylbenzene (1313762-49-0) → 2-bromo-5-chlorobenzaldehyde (174265-12-4)

Guidance literature:

With sulfuric acid; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c1cc10683j

Reference yield: 92.0%

2-bromo-5-chlorobenzyl bromide (66192-24-3) → 2-bromo-5-chlorobenzaldehyde (174265-12-4)

Guidance literature:

With 4-methylmorpholine N-oxide; In acetonitrile; at 0 ℃; for 2h; Molecular sieve;

upstream raw materials:

2-bromo-5-chlorobenzyl bromide

2-bromo-5-chlorotoluene

chromium(VI) oxide

(2-bromo-5-chlorophenyl)methanediyl diacetate

Downstream raw materials:

2-chloro-9-[(4-methylphenyl)sulfonylamino]fluorene

C₂₀H₁₆ClNO₂S

6-chloro-1-indanone

2-vinyl-5-chlorobenzaldehyde

Refernces

• 1、 Abengózar, Alberto,García-García, Patricia,Sucunza, David,Pérez-Redondo, Adrián,Vaquero, Juan J.. "Synthesis of functionalized helical BN-benzo[c] phenanthrenes". . p. 2467 - 2470. Retrieved 2018/03/21.
• 2、 -. "A gold catalytic oxidation of benzyl alcohol synthesis method (by machine translation)". Paragraph 0034-0037; 0041; 0055-0057. . Retrieved 2017/08/25.