(-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide

Base Information

• Chemical Name: (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide
• CAS No.: 1070872-63-7
• Molecular Formula: C₁₉H₂₄F₃NO₄
• Molecular Weight: 387.399

Synonyms:(-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide

Chemical Property of (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide

Chemical Property:

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Technology Process of (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide

There total 1 articles about (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,5R)-2,2-dimethyl-5-(2,2,2-trifluoro-1-phenyl-1-trimethylsilanyloxy-ethyl)-[1,3]dioxolane-4-carboxylic acid dimethylamide + 3-chloroprop-1-ene (107-05-1) → (4R,5R)-5-((S)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide + (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide (1070872-63-7)

Guidance literature:

With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; for 3h;

DOI:10.1021/jo8013403

Reference yield: 94.0%

(-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide (1070872-63-7) → (-)-(R)-2-allyloxy-3,3,3-trifluoro-2-phenyl-propanal (1070872-68-2)

Guidance literature:

With periodic acid; trifluoroacetic acid; In water; at 20 ℃; for 2h;

DOI:10.1021/jo8013403

Reference yield: 94.0%

(-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide (1070872-63-7) + phenylmagnesium bromide (100-58-3) → (-)-(4R,5R)-[5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]phenylmethanone (1337967-75-5)

Guidance literature:

In tetrahydrofuran; for 3h;

DOI:10.1002/chem.201100551

upstream raw materials:

3-chloroprop-1-ene

Downstream raw materials:

(-)-(2R,3R,4R)-4-allyloxy-5,5,5-trifluoro-2,3-dihydroxy-4-phenyl-pentanoic acid dimethylamide

(-)-(R)-2-allyloxy-3,3,3-trifluoro-2-phenyl-propanal

(-)-(4R,5R)-[5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]phenylmethanone

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