2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

Base Information

Chemical Name:2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile
CAS No.:1257761-38-8
Molecular Formula:C₁₅H₁₃ClF₂N₄
Molecular Weight:322.745
Hs Code.:

Synonyms:2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

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Chemical Property of 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

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Technology Process of 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

There total 1 articles about 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 654-01-3
(2,6-difluorophenyl)acetonitrile

: 61770-00-1
4,6-dichloro-N,N,5-trimethylpyrimidine-2-amine

: 1257761-38-8
2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃;
DOI:10.1002/ardp.201600008

Reference yield: 86.3%

: 1257761-38-8
2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

: 74-88-4
methyl iodide

: 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)propanenitrile

Guidance literature:: 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1039/c5ob02055g

Reference yield: 14.0%

: 67-56-1
methanol

: 1257761-38-8
2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile

: 4-(2,6-difluorobenzyl)-6-methoxy-N,N,5-trimethylpyrimidin-2-amine

Guidance literature:: methanol; 2-[6-chloro-2-(dimethylamino)-5-methylpyrimidin-4-yl]-2-(2,6-difluorophenyl)acetonitrile; With sodium hydroxide; In water; for 30h; Reflux;

With water;
DOI:10.1002/ardp.201600008