5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide

Base Information

• Chemical Name: 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide
• CAS No.: 1586765-14-1
• Molecular Formula: C₂₁H₂₀FN₅O₂
• Molecular Weight: 393.421

Synonyms:5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide

Chemical Property of 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide

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Technology Process of 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide

There total 2 articles about 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-methyl-1-(4-methoxyphenyl)-1,2,3-triazol-4-carbonyl chloride (88958-25-2) + 5-Fluorotryptamine hydrochloride (2711-58-2) → 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide (1586765-14-1)

Guidance literature:

With potassium carbonate; In dichloromethane; 1,2-dichloro-ethane; at 25 ℃; for 12h;

DOI:10.1134/S1070428014020225

Reference yield:

1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (31802-54-7) → 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide (1586765-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: potassium carbonate / 1,2-dichloro-ethane; dichloromethane / 12 h / 25 °C

With thionyl chloride; potassium carbonate; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1134/S1070428014020225

Reference yield: 75.0%

5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide (1586765-14-1) → 1-[5-methyl-1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-6-fluoro-4,9-dihydro-3H-β-carboline (1586765-20-9)

Guidance literature:

With phosphorus pentoxide; trichlorophosphate; In toluene; at 110 ℃; for 12h;

DOI:10.1134/S1070428014020225

upstream raw materials:

5-methyl-1-(4-methoxyphenyl)-1,2,3-triazol-4-carbonyl chloride

5-Fluorotryptamine hydrochloride

1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

Downstream raw materials:

1-[5-methyl-1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-6-fluoro-4,9-dihydro-3H-β-carboline

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