3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide

Base Information

• Chemical Name: 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide
• CAS No.: 1462886-21-0
• Molecular Formula: Br*C₁₈H₂₁N₂O₆
• Molecular Weight: 441.279
• Mol file: 1462886-21-0.mol

Synonyms:3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide

Chemical Property of 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide

There total 3 articles about 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyl 1-(2-ethoxy-2-oxoethyl)-1H-imidazole-4,5-dicarboxylate (1462886-37-8) + benzyl bromide (100-39-0) → 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide (1462886-21-0)

Guidance literature:

In acetonitrile; at 20 ℃; for 72h;

DOI:10.1039/c3gc40975a

Reference yield:

dimethyl imidazole-4,5-dicarboxylate (3304-70-9) → 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide (1462886-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 48 h / 20 °C / Inert atmosphere

2: acetonitrile / 72 h / 20 °C

With potassium carbonate; In acetonitrile;

DOI:10.1039/c3gc40975a

Reference yield:

4,5-imidazoledicarboxylic acid (570-22-9) → 3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium bromide (1462886-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 24 h / Reflux

2: potassium carbonate / acetonitrile / 48 h / 20 °C / Inert atmosphere

3: acetonitrile / 72 h / 20 °C

With sulfuric acid; potassium carbonate; In acetonitrile;

DOI:10.1039/c3gc40975a

upstream raw materials:

dimethyl 1-(2-ethoxy-2-oxoethyl)-1H-imidazole-4,5-dicarboxylate

benzyl bromide

4,5-imidazoledicarboxylic acid

dimethyl imidazole-4,5-dicarboxylate

Downstream raw materials:

3-benzyl-1-(2-ethoxy-2-oxoethyl)-4,5-bis(methoxycarbonyl)-1H-imidazol-3-ium tetrafluoroborate