2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate
CAS No.:1376514-33-8
Molecular Formula:C₂₈H₃₆BrN₃O₄S
Molecular Weight:590.582
Hs Code.:

Synonyms:2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Chemical Property of 2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Technology Process of 2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

There total 5 articles about 2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1376514-32-7
2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-ol

: 1376514-33-8
2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 30 ℃; for 7h;

Reference yield:

: 139102-34-4
methyl 4-bromo-2-methoxybenzoate

: 1376514-33-8
2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride; ethanol / tetrahydrofuran / 18 h

2.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

3.2: 16 h / 70 °C

4.1: methanol / 16 h / 65 °C

5.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

With 1,4-diaza-bicyclo[2.2.2]octane; lithium borohydride; ethanol; phosphorus tribromide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

Reference yield:

: 854778-42-0
4-bromo-1-(bromomethyl)-2-methoxybenzene

: 1376514-33-8
2-amino-5-(4-bromo-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride; In tetrahydrofuran; methanol; mineral oil;