1-Chloroisobutyl propionate

Base Information

• Chemical Name: 1-Chloroisobutyl propionate
• CAS No.: 58304-65-7
• Molecular Formula: C7H13ClO2
• Molecular Weight: 164.632
• Hs Code.: 2915509000
• Mol file: 58304-65-7.mol

Synonyms:1-Propanol,1-chloro-2-methyl-, propanoate (9CI);1-Chloro-2-methylpropyl propanoate;1-Chloroisobutyl propionate;

Chemical Property of 1-Chloroisobutyl propionate

Chemical Property:

• Vapor Pressure: 1.77mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 166.7 °C at 760 mmHg
• Flash Point: 56.3 °C
• PSA: 26.30000
• Density: 1.03 g/cm³
• LogP: 2.16050
• Storage Temp.: 2-8°C
• Solubility.: Chloroform

Purity/Quality:

98% ^*data from raw suppliers

1-Chloroisobutylpropionate(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Fosinopril Intermediate in the preparation of Fosinopril (F727800) derivatives.

Technology Process of 1-Chloroisobutyl propionate

There total 2 articles about 1-Chloroisobutyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

propionyl chloride (79-03-8) + isobutyraldehyde (78-84-2) → propanoic acid,1-chloro-2-methylpropyl ester (58304-65-7)

Guidance literature:

at 0 - 5 ℃; for 4h;

Reference yield:

→ propanoic acid,1-chloro-2-methylpropyl ester (58304-65-7)

Guidance literature:

Reference yield: 45.0%

vemurafenib (1029872-54-5,918504-65-1) + propanoic acid,1-chloro-2-methylpropyl ester (58304-65-7) → 1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-methylpropyl propionate (1567346-91-1)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In N,N-dimethyl-formamide; at 10 ℃; for 3.5h;

upstream raw materials:

propionyl chloride

isobutyraldehyde

Downstream raw materials:

2-methyl-1-(1-oxopropoxy)propyl-2-butyl-6-ethoxy-3-<<2'-1H-tetrazol-5-yl<1,1'-biphenyl>-4-yl>oxy>-5-quinoxalinecarboxylate

[3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[2-methyl-1-(1-oxopropoxy)propyl] ester

[[2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid

1-(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-2-methylpropyl propionate

Refernces

• 1、 -. "SUBSTITUTED AZAINDOLE COMPOUNDS, SALTS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS OF USE". Paragraph 0306-0308. . Retrieved 2014/03/24.
• 2、 -. "GABA ANALOGS, COMPOSITIONS, AND METHODS FOR MANUFACTURING THEREOF". Page/Page column 23-24. . Retrieved 2009/10/22.