2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Base Information

Chemical Name:2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide
CAS No.:1439936-44-3
Molecular Formula:C₂₆H₂₄FN₃O₄S
Molecular Weight:493.559
Hs Code.:

Synonyms:2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Suppliers and Price of 2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

There total 6 articles about 2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 402-65-3
2-fluoropyridine-4-carboxylic acid

: 1439936-21-6
4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-amine

: 1439936-44-3
2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 51980-60-0
(4-(2-methoxyethoxy)phenol)

: 1439936-44-3
2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

2: tetrabutylammomium bromide / acetonitrile / 20 °C

3: ethanol / 2 h / Reflux

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With potassium phosphate; tetrabutylammomium bromide; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tert-butyl XPhos; In ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 83759-88-0
1-(4-amino-2,6 dimethylphenyl)ethanone

: 1439936-44-3
2-fluoro-N-(4-{4-(4-(2-methoxyethoxy)phenoxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: tert.-butylnitrite; copper dichloride / acetonitrile

2: potassium phosphate; tert-butyl XPhos; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

3: tetrabutylammomium bromide / acetonitrile / 20 °C

4: ethanol / 2 h / Reflux

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With potassium phosphate; tert.-butylnitrite; tetrabutylammomium bromide; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper dichloride; tert-butyl XPhos; In ethanol; dichloromethane; toluene; acetonitrile;