(Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane

Base Information

• Chemical Name: (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane
• CAS No.: 1279102-60-1
• Molecular Formula: C₁₇H₂₄OSi
• Molecular Weight: 272.462
• Mol file: 1279102-60-1.mol

Synonyms:(Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane

Chemical Property of (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane

There total 7 articles about (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

chloro-trimethyl-silane (75-77-4) + (2-methylcyclohex-1-en-1-yl)(phenyl)methanone (32704-49-7) → (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane (1279102-60-1)

Guidance literature:

(2-methylcyclohex-1-en-1-yl)(phenyl)methanone; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/ja111067j

Reference yield:

α-(2-bromocyclohexen-1-yl)benzyl alcohol (1228319-68-3) → (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane (1279102-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: iron(III)-acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / -78 °C

3.2: -78 °C

With n-butyllithium; iron(III)-acetylacetonate; diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane;

DOI:10.1021/ja111067j

Reference yield:

2-benzoylcyclohex-1-en-1-yl diethyl phosphate (1279102-43-0) → (Z)-trimethyl((2-methylenecyclohexylidene)(phenyl)methoxy)silane (1279102-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide / diethyl ether / 1 h / -78 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: -78 °C

With copper(l) iodide; n-butyllithium; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ja111067j

upstream raw materials:

(2-bromocyclohex-1-en-1-yl)(phenyl)methanone

chloro-trimethyl-silane

(2-methylcyclohex-1-en-1-yl)(phenyl)methanone

α-(2-bromocyclohexen-1-yl)benzyl alcohol

Downstream raw materials:

2-(4-phenyl-1,2,5,6,7,8-hexahydronaphthalen-2-yl)furan

6-(3-bromophenyl)-8-phenyl-1,2,3,4,5,6-hexahydronaphthalene

6-(2-bromocyclohex-1-en-1-yl)-8-phenyl-1,2,3,4,5,6-hexahydronaphthalene

6-(4-methoxyphenyl)-8-phenyl-1,2,3,4,5,6-hexahydronaphthalene