Creatine ethyl ester hydrochloride

Base Information

• Chemical Name: Creatine ethyl ester hydrochloride
• CAS No.: 15366-32-2
• Molecular Formula: C6H14ClN3O2
• Molecular Weight: 195.649
• Hs Code.: 2925290090
• Mol file: 15366-32-2.mol

Synonyms:Creatine,ethyl ester, monohydrochloride (8CI);Glycine, N-(aminoiminomethyl)-N-methyl-,ethyl ester, monohydrochloride (9CI);Ethyl N-carbamimidoyl-N-methylglycinate hydrochloride (1:1);

Chemical Property of Creatine ethyl ester hydrochloride

Chemical Property:

• Melting Point: 162-165 °C
• PSA: 79.41000
• LogP: 0.97680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(1-methylguanidino)acetatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Creatine ethyl ester hydrochloride

There total 5 articles about Creatine ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethanol (64-17-5) + Creatinine (57-00-1) → ethyl 2-(3-methylguanidino)acetate hydrochloride (15366-32-2)

Guidance literature:

With phosgene; dmap; at 10 ℃; for 0.5h; Reagent/catalyst; Sealed tube;

Reference yield: 80.0%

ethanol (64-17-5) + Creatinine (57-00-1) → ethyl 2-(3-methylguanidino)acetate hydrochloride (15366-32-2) + ethyl acetate (141-78-6)

Guidance literature:

ethanol; With acetyl chloride; at 35 - 60 ℃;

Creatinine; at 35 - 50 ℃; for 2 - 8h;

Reference yield: 48.0%

Creatinine (57-00-1) → ethyl 2-(3-methylguanidino)acetate hydrochloride (15366-32-2)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethanol

Creatinine

creatinine

Downstream raw materials:

creatinine

Refernces

• 1、 -. "Creatine ester anti-inflammatory compounds and formulations". Sheet 8/18. . Retrieved 2018/01/10.
• 2、 -. "Creatine phosphate prodrugs, compositions and uses thereof". Page/Page column 53-54. . Retrieved 2010/11/29.