(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Base Information

Chemical Name:(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid
CAS No.:210548-01-9
Molecular Formula:C₃₂H₅₁N₃O₇
Molecular Weight:589.773
Hs Code.:

Synonyms:(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

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Chemical Property of (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

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Technology Process of (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

There total 11 articles about (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 188743-71-7
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

: 210548-01-9
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1021/ja963968x

Reference yield:

: 157505-72-1
(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

: 210548-01-9
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / CH₂Cl₂ / 14 h / Ambient temperature

2: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

3: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

4: LiOH

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o

Reference yield:

: 171287-53-9
(S)-2-Benzyloxycarbonylamino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

: 210548-01-9
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

2: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

3: LiOH

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o