N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine

Base Information

• Chemical Name: N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine
• CAS No.: 608122-30-1
• Molecular Formula: C₂₂H₂₉F₂N₃O₅Si
• Molecular Weight: 481.572
• Mol file: 608122-30-1.mol

Synonyms:N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine

Chemical Property of N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine

There total 3 articles about N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N4-benzoyl-2'-deoxy-2',2'-difluorocytidine (142816-70-4) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine (608122-30-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm020571x

Reference yield:

benzoic acid anhydride (93-97-0) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine (608122-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / ethanol / 4 h / Heating

2: 64 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020571x

Reference yield:

gemcitabine (95058-81-4,103882-85-5) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine (608122-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / ethanol / 4 h / Heating

2: 64 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020571x

upstream raw materials:

tert-butyldimethylsilyl chloride

N⁴-benzoyl-2'-deoxy-2',2'-difluorocytidine

benzoic acid anhydride

gemcitabine

Downstream raw materials:

(N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetyl-5'-monophosphate-1-dodecylthio-2-decyloxypropyl)cytidine

N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetylcytidine

N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine