N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine

Base Information

• Chemical Name: N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine
• CAS No.: 608122-31-2
• Molecular Formula: C₂₄H₃₁F₂N₃O₆Si
• Molecular Weight: 523.609
• Mol file: 608122-31-2.mol

Synonyms:N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine

Chemical Property of N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine

There total 5 articles about N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetic anhydride (108-24-7) + N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine (608122-30-1) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine (608122-31-2)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1021/jm020571x

Reference yield:

benzoic acid anhydride (93-97-0) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine (608122-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / ethanol / 4 h / Heating

2: 64 percent / imidazole / dimethylformamide / 20 °C

3: 92 percent / pyridine / 24 h / 20 °C

With pyridine; 1H-imidazole; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020571x

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluoro-3-acetylcytidine (608122-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / imidazole / dimethylformamide / 20 °C

2: 92 percent / pyridine / 24 h / 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jm020571x

upstream raw materials:

acetic anhydride

N-benzoyl-5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine

tert-butyldimethylsilyl chloride

benzoic acid anhydride

Downstream raw materials:

(N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetyl-5'-monophosphate-1-dodecylthio-2-decyloxypropyl)cytidine

N-benzoyl-2'-deoxy-2',2'-difluoro-3-acetylcytidine