((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

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Chemical Name:((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol
CAS No.:1272667-39-6
Molecular Formula:C₂₆H₃₂N₄O₃
Molecular Weight:448.565
Hs Code.:

Synonyms:((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

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Chemical Property of ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

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Technology Process of ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

There total 10 articles about ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272666-89-3
2-(3-((7-oxabicyclo[2.2.1]heptan-1-yl)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1272667-35-2
((1S,4S)-4-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

: 1272667-39-6
((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1272667-39-6
((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -10 °C

1.2: 4 h / -10 - 20 °C

2.1: water; oxalic acid / acetone / 3 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

4.1: N-iodo-succinimide / acetonitrile / 20 °C

5.1: potassium carbonate / acetonitrile / 18 h / 150 °C / Pressure vessel

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; N-iodo-succinimide; n-butyllithium; water; oxalic acid; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 51656-90-7
8-methylene-1,4-dioxaspiro[4.5]decane

: 1272667-39-6
((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: water; oxalic acid / acetone / 3 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

3: N-iodo-succinimide / acetonitrile / 20 °C

4: potassium carbonate / acetonitrile / 18 h / 150 °C / Pressure vessel

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; N-iodo-succinimide; water; oxalic acid; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;