Ethanone, 1,2-diphenyl-2-(phenylthio)-

Base Information

• Chemical Name: Ethanone, 1,2-diphenyl-2-(phenylthio)-
• CAS No.: 16222-09-6
• Molecular Formula: C₂₀H₁₆OS
• Molecular Weight: 304.412
• NSC Number: 157933
• DSSTox Substance ID: DTXSID80303344
• Nikkaji Number: J909.474A
• Mol file: 16222-09-6.mol

Synonyms:16222-09-6;ethanone, 1,2-diphenyl-2-(phenylthio)-;Phenyl-desyl-sulfid;NSC157933;SCHEMBL10882291;DTXSID80303344;AKOS024383608;NSC-157933

Chemical Property of Ethanone, 1,2-diphenyl-2-(phenylthio)-

Chemical Property:

• Vapor Pressure: 1.63E-08mmHg at 25°C
• Boiling Point: 456.3°Cat760mmHg
• Flash Point: 252.5°C
• Density: 1.19g/cm³
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 304.09218630
• Heavy Atom Count: 22
• Complexity: 336

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)SC3=CC=CC=C3

Technology Process of Ethanone, 1,2-diphenyl-2-(phenylthio)-

There total 24 articles about Ethanone, 1,2-diphenyl-2-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

α-chloro-α-(phenylthio)acetophenone (67655-17-8) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1,2-diphenyl-2-(phenylthio)ethanone (16222-09-6,132187-17-8,132257-22-8)

Guidance literature:

With tin(IV) chloride; Ambient temperature;

DOI:10.1016/S0040-4039(00)81343-X

Reference yield: 83.0%

phenyl benzyl ketone (451-40-1) + diphenyldisulfane (882-33-7) → 1,2-diphenyl-2-(phenylthio)ethanone (16222-09-6,132187-17-8,132257-22-8)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); 1,2-bis-(diphenylphosphino)ethane; In N,N-dimethyl acetamide; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2012.07.132

Reference yield: 83.0%

2-(dimethyl(oxo)-λ6-sulfanylidene)-1,2-diphenylethan-1-one + thiophenol (108-98-5) → 1,2-diphenyl-2-(phenylthio)ethanone (16222-09-6,132187-17-8,132257-22-8)

Guidance literature:

In acetonitrile; at 25 ℃; for 24h;

DOI:10.1021/acs.orglett.8b03126

upstream raw materials:

α-acetoxy-α-phenylsulfanyl-stilbene

sodium thiophenolate

Desyl chloride

trans-1,2-diphenyl-2-phenylthiovinyl tosylate

Downstream raw materials:

phenyl benzyl ketone

2,3-diphenylbenzo[b]thiophene

benzil

diphenyldisulfane