{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

Base Information

Chemical Name:{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol
CAS No.:1354060-40-4
Molecular Formula:C₁₉H₁₈Cl₂N₂O₂
Molecular Weight:377.27
Hs Code.:

Synonyms:{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

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Chemical Property of {1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

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Technology Process of {1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

There total 4 articles about {1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1354060-39-1
1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1354060-40-4
{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

Guidance literature:: 1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; diethyl ether;

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1354060-40-4
{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 17 h / 20 °C / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1354060-40-4
{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; potassium iodide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;