1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

Base Information

Chemical Name:1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde
CAS No.:1354060-41-5
Molecular Formula:C₁₉H₁₆Cl₂N₂O₂
Molecular Weight:375.254
Hs Code.:

Synonyms:1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

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Chemical Property of 1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

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Technology Process of 1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

There total 5 articles about 1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1354060-40-4
{1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-methanol

: 1354060-41-5
1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 1354060-41-5
1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 17 h / 20 °C / Reflux

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; acetic acid; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1354060-41-5
1-[5-chloro-2-(4-chloro-benzyloxy)-benzyl]-5-methyl-1H-pyrazole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; potassium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;