Sucrose-6-acetic ester

Base Information

• Chemical Name: Sucrose-6-acetic ester
• CAS No.: 63648-81-7
• Molecular Formula: C14H24 O12
• Molecular Weight: 384.337
• Mol file: 63648-81-7.mol

Synonyms:Sucrose6-acetate

Chemical Property of Sucrose-6-acetic ester

Chemical Property:

• Melting Point: 116 - 118°C
• Boiling Point: 674.6±55.0 °C(Predicted)
• PKA: 12.79±0.70(Predicted)
• PSA: 195.60000
• Density: 1.66±0.1 g/cm3(Predicted)
• LogP: -4.82480
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Ethanol (Slightly), Water (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

Sucrose-6-acetic ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sucralose 6-Acetate is a useful intermediate in the synthesis of Sucralose, an intensive sweetening agent of safety with no calories. A halogenated analogue of sucrose.

Technology Process of Sucrose-6-acetic ester

There total 12 articles about Sucrose-6-acetic ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

acetic anhydride (108-24-7) + Sucrose (57-50-1) → 6-O-acetyl sucrose (63648-81-7,936001-72-8)

Guidance literature:

Sucrose; With di(n-butyl)tin oxide; In cyclohexane; N,N-dimethyl-formamide; at 60 - 95 ℃; for 5h;

acetic anhydride; In cyclohexane; N,N-dimethyl-formamide; at 5 - 20 ℃; for 4.5h;

Reference yield: 79.0%

ethyl acetate (141-78-6) + Sucrose (57-50-1) → 6-O-acetyl sucrose (63648-81-7,936001-72-8)

Guidance literature:

SO₄^(2-)-TiO₂/Al₂O₃; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

1,3-di-(6-O-sucrose)-1,1,3,3-tetrabutyl-distannoxane + acetic anhydride (108-24-7) → sucrose 4-acetate (63648-80-6) + 6-O-acetyl sucrose (63648-81-7,936001-72-8) + Sucrose (57-50-1)

Guidance literature:

In N,N-dimethyl-formamide; isopropyl alcohol; at 0 - 20 ℃; for 5.5h; Product distribution / selectivity;

upstream raw materials:

acetic anhydride

Sucrose

Acetyl cyanide

ethyl acetate

Downstream raw materials:

sucralose-6-acetate

Sucralose

2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3-O-acetyl-1,4,6-trichloro-1,4,6-trideoxy-β-D-fructofuranoside

2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside

Refernces

• 1、 -. "Monotin organic compound, preparation method and application thereof". Paragraph 0101-0112. . Retrieved 2021/05/08.
• 2、 -. "Preparation method of sucrose-6-acetate". Paragraph 0009-0013. . Retrieved 2019/04/17.