Name: Sucrose-6-acetic ester
SKU: 63648-81-7

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Pharmaceutical (25)
Organic Chemicals (8)
Others (7)

Basic Information

Molecular Structure:
CAS No.:	63648-81-7
Name:	Sucrose-6-acetic ester

Formula:	C14H24 O12
Molecular Weight:	384.337
Synonyms:	Sucrose6-acetate
Density:	1.66±0.1 g/cm3(Predicted)
Melting Point:	116 - 118°C
Boiling Point:	674.6±55.0 °C(Predicted)
PSA:	195.60000
LogP:	-4.82480

Synthetic route

: 108-24-7
acetic anhydride

: 57-50-1
Sucrose

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
Stage #1: Sucrose With di(n-butyl)tin oxide In cyclohexane; N,N-dimethyl-formamide at 60 - 95℃; for 5h; Stage #2: acetic anhydride In cyclohexane; N,N-dimethyl-formamide at 5 - 20℃; for 4.5h;	98.6%
Stage #1: Sucrose With 1,3-diacetoxy-1,1,3,3-tetrabutyldistannoxane In cyclohexane; N,N-dimethyl-formamide for 0.08h; Heating / reflux; Azeotropic water co-distillation; Stage #2: acetic anhydride In cyclohexane; N,N-dimethyl-formamide at 10℃; for 2h;
Stage #1: Sucrose; di(n-butyl)tin oxide In N,N-dimethyl-formamide at 80 - 85℃; for 10 - 13h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 0 - 20℃; for 3 - 4h; Product distribution / selectivity;

: 141-78-6
ethyl acetate

: 57-50-1
Sucrose

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
SO4(2-)-TiO2/Al2O3 In N,N-dimethyl-formamide at 80℃; for 6h;	79%

: 108-24-7
acetic anhydride

: 57-50-1
Sucrose

A: 63648-81-7
6-O-acetyl sucrose

B: 4,6-di-O-acetate sucrose

Conditions

Conditions	Yield
With pyridine; polymer-supported butyltin(IV) species 1.) MeOH, reflux, 12 h, 2.) DMF, RT, 1 d; Yield given. Multistep reaction. Yields of byproduct given;
With pyridine; polymer-supported butyltin(IV) species 1.) MewOH, reflux, 12 h, 2.) DMF, RT, 1 d; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: C16H29NO11

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
With water; acidic ion exchange resin In N,N-dimethyl-formamide for 0.5h; pH=~ 6; Product distribution / selectivity;
With water; acetic acid In N,N-dimethyl-formamide at 20℃; for 0.5h; pH=6.5; Product distribution / selectivity;

: 631-57-2
Acetyl cyanide

: 57-50-1
Sucrose

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 40 - 50℃; for 6h; Product distribution / selectivity;
In N,N,N,N,N,N-hexamethylphosphoric triamide at 20℃; for 4h; Product distribution / selectivity;
In acetonitrile at 60℃; for 2h; Product distribution / selectivity;

: 108-24-7
acetic anhydride

: 818-08-6
di(n-butyl)tin oxide

: 57-50-1
Sucrose

A: 63648-80-6
sucrose 4-acetate

B: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
Stage #1: di(n-butyl)tin oxide; Sucrose With isopropyl alcohol In N,N-dimethyl-formamide at 100℃; for 5h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 10 - 27℃; for 6h; Product distribution / selectivity;

...Expand

: 1,3-di-(6-O-sucrose)-1,1,3,3-tetrabutyl-distannoxane

: 108-24-7
acetic anhydride

A: 63648-80-6
sucrose 4-acetate

B: 63648-81-7
6-O-acetyl sucrose

C: 57-50-1
Sucrose

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; isopropyl alcohol at 0 - 20℃; for 5.5h; Product distribution / selectivity;

...Expand

: 1,3-di-(6-O-sucrose)-1,1,3,3-tetrabutyl-distannoxane

: 108-24-7
acetic anhydride

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; isopropyl alcohol at 0 - 20℃; Product distribution / selectivity;

: 956499-32-4
1,3(diO-sucrose)dibutyl stannylene

: 108-24-7
acetic anhydride

: 63648-81-7
6-O-acetyl sucrose

Conditions

Conditions	Yield
Stage #1: 1,3(diO-sucrose)dibutyl stannylene In N,N-dimethyl-formamide at 40 - 45℃; for 0.5h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 0 - 20℃; for 3 - 4h; Product distribution / selectivity;