1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

Base Information

Chemical Name:1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester
CAS No.:111223-30-4
Molecular Formula:C₂₆H₃₄NO₆P
Molecular Weight:487.533
Hs Code.:

Synonyms:1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

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Chemical Property of 1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

Chemical Property:

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Technology Process of 1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

There total 4 articles about 1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 768-94-5
1-Adamantanamine

: 111223-20-2
4-phenylbutylphosphonyl dichloride

: 80089-25-4
pyrrolidine-2-carboxylic acid benzyl ester

: 79-31-2
isobutyric Acid

: 111223-30-4
1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 46348-61-2
4-phenyl-butyl phosphonic acid

: 111223-30-4
1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / PCl₅

2: triethylamine / tetrahydrofuran / 6 h / -78 - 20 °C

3: tetrahydrofuran / 12 h / Ambient temperature

With phosphorus pentachloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)85232-6

Reference yield:

: 111223-20-2
4-phenylbutylphosphonyl dichloride

: 111223-30-4
1-[2,2-Dimethyl-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxoethyl]-L-proline benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 6 h / -78 - 20 °C

2: tetrahydrofuran / 12 h / Ambient temperature

With triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)85232-6