[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

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Chemical Name:[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine
CAS No.:1217490-81-7
Molecular Formula:C₂₁H₂₉N₅O₄
Molecular Weight:415.492
Hs Code.:

Synonyms:[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

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Chemical Property of [8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

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Technology Process of [8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

There total 11 articles about [8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

: 1217490-78-2
[8-(4-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

: 1217490-81-7
[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 0.5h;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-72-6
trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

: 1217490-81-7
[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; bis(tri-n-butyltin); lithium chloride; In 1,4-dioxane; at 110 ℃; for 22h; Inert atmosphere;

With trifluoroacetic acid; In acetonitrile; at 100 ℃; for 0.0833333h;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-54-4
2-(4-benzyloxy-2,6-dimethoxyphenyl)-3-oxobutyronitrile

: 1217490-81-7
[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrazine hydrate; acetic acid / toluene / 5 h / Reflux

2.1: acetonitrile / 18 h / 20 °C

3.1: sodium ethanolate / ethanol / 6 h / Reflux

4.1: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

5.1: tetrahydrofuran / 1 h

6.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

7.1: pyridine / 0 - 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; hexamethyldistannane; lithium chloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

8.2: 1 h / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; palladium 10% on activated carbon; N,N-diethyl-p-toluidine; hydrogen; sodium ethanolate; hexamethyldistannane; hydrazine hydrate; acetic acid; lithium chloride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; acetonitrile;
DOI:10.1002/jlcr.1616