trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester
CAS No.:1217490-72-6
Molecular Formula:C₂₂H₂₈F₃N₅O₇S
Molecular Weight:563.555
Hs Code.:

trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

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Chemical Property of trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

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Technology Process of trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

There total 8 articles about trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1217490-69-1
4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

: 1217490-72-6
trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

Guidance literature:: With pyridine; at 0 - 20 ℃;
DOI:10.1002/jlcr.1616

Reference yield:

: 22080-96-2
syringaldehyde

: 1217490-72-6
trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / acetone / 14 h / Reflux

2: potassium tert-butylate / 1,2-dimethoxyethane / 3 h / -60 - -50 °C

3: sodium / 1.83 h / Reflux

4: hydrazine hydrate; acetic acid / toluene / 5 h / Reflux

5: acetonitrile / 18 h / 20 °C

6: sodium ethanolate / ethanol / 6 h / Reflux

7: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

8: tetrahydrofuran / 1 h

9: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

10: pyridine / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; N,N-diethyl-p-toluidine; potassium tert-butylate; hydrogen; sodium ethanolate; sodium; potassium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; acetone; toluene; acetonitrile;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-62-4
8-(4-benzyloxy-2,6-dimethoxyphenyl)-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one

: 1217490-72-6
trifluoromethanesulfonic acid 4-{4-[bis(2-methoxyethyl)amino]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

2: tetrahydrofuran / 1 h

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

4: pyridine / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; N,N-diethyl-p-toluidine; hydrogen; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1002/jlcr.1616