4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

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Chemical Name:4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol
CAS No.:1217490-69-1
Molecular Formula:C₂₁H₂₉N₅O₅
Molecular Weight:431.492
Hs Code.:

Synonyms:4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

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Chemical Property of 4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

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Technology Process of 4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

There total 8 articles about 4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1217490-66-8
[8-(4-benzyloxy-2,6-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

: 1217490-69-1
4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;
DOI:10.1002/jlcr.1616

Reference yield:

: 22080-96-2
syringaldehyde

: 1217490-69-1
4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / acetone / 14 h / Reflux

2: potassium tert-butylate / 1,2-dimethoxyethane / 3 h / -60 - -50 °C

3: sodium / 1.83 h / Reflux

4: hydrazine hydrate; acetic acid / toluene / 5 h / Reflux

5: acetonitrile / 18 h / 20 °C

6: sodium ethanolate / ethanol / 6 h / Reflux

7: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

8: tetrahydrofuran / 1 h

9: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; N,N-diethyl-p-toluidine; potassium tert-butylate; hydrogen; sodium ethanolate; sodium; potassium carbonate; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; acetone; toluene; acetonitrile;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-62-4
8-(4-benzyloxy-2,6-dimethoxyphenyl)-2,7-dimethyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one

: 1217490-69-1
4-{[bis(2-methoxyethyl)amino]-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-3,5-dimethoxyphenol

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

2: tetrahydrofuran / 1 h

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; N,N-diethyl-p-toluidine; hydrogen; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1002/jlcr.1616