[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Base Information

Chemical Name:[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine
CAS No.:1217490-84-0
Molecular Formula:C₂₁H₂₈BrN₅O₄
Molecular Weight:494.388
Hs Code.:

Synonyms:[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

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Chemical Property of [8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

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Technology Process of [8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

There total 12 articles about [8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1217490-81-7
[8-(2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

: 1217490-84-0
[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-53-3
(4-benzyloxy-2,6-dimethoxyphenyl)acetonitrile

: 1217490-84-0
[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium / 1.83 h / Reflux

2.1: hydrazine hydrate; acetic acid / toluene / 5 h / Reflux

3.1: acetonitrile / 18 h / 20 °C

4.1: sodium ethanolate / ethanol / 6 h / Reflux

5.1: N,N-diethyl-p-toluidine; trichlorophosphate / 24 h / Reflux

6.1: tetrahydrofuran / 1 h

7.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

8.1: pyridine / 0 - 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; hexamethyldistannane; lithium chloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

9.2: 1 h / 20 °C

10.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h

11.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / 20 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; palladium 10% on activated carbon; N,N-diethyl-p-toluidine; hydrogen; sodium ethanolate; hexamethyldistannane; sodium; hydrazine hydrate; acetic acid; lithium chloride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; acetonitrile;
DOI:10.1002/jlcr.1616

Reference yield:

: 1217490-63-5
8-(4-benzyloxy-2,6-dimethoxyphenyl)-4-chloro-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazine

: 1217490-84-0
[8-(3-bromo-2,6-dimethoxyphenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]bis(2-methoxyethyl)amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 1 h

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

3.1: pyridine / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; hexamethyldistannane; lithium chloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h

6.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / 20 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; palladium 10% on activated carbon; hydrogen; hexamethyldistannane; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1002/jlcr.1616