N-(2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl)-formamide

Base Information

• Chemical Name: N-(2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl)-formamide
• CAS No.: 68360-20-3
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.343
• European Community (EC) Number: 684-607-1
• Mol file: 68360-20-3.mol

Synonyms:N-(2-(3-BENZYLOXY-4-METHOXY-PHENYL)-ETHYL)-FORMAMIDE;AKOS024322339;68360-20-3;E83139;N-(3-(Benzyloxy)-4-methoxyphenethyl)formamide

Chemical Property of N-(2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl)-formamide

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 285.13649347
• Heavy Atom Count: 21
• Complexity: 292

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCNC=O)OCC2=CC=CC=C2

Technology Process of N-(2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl)-formamide

There total 6 articles about N-(2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl)-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-benzyloxy-4-methoxyphenylethylamine (36455-21-7) + formic acid ethyl ester (109-94-4) → N-formyl-3-benzyloxy-4-methoxyphenethylamine (68360-20-3)

Guidance literature:

for 24h; Reflux;

DOI:10.1016/j.bmc.2017.02.005

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → N-formyl-3-benzyloxy-4-methoxyphenethylamine (68360-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 4>OAc / acetic acid / Heating

2: methanol

3: Heating

With ammonium acetate; In methanol; acetic acid;

DOI:10.1016/0040-4020(61)80086-0

Reference yield:

benzyl bromide (100-39-0) → N-formyl-3-benzyloxy-4-methoxyphenethylamine (68360-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 96 h / Reflux

2: acetic acid; ammonium acetate / 3 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / Reflux

4: 24 h / Reflux

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1016/j.bmc.2017.02.005

upstream raw materials:

3-benzyloxy-4-methoxyphenylethylamine

formic acid ethyl ester

formic acid

2-(benzyloxy)-1-methoxy-4-(1-methoxy-2-nitroethyl) Benzene

Downstream raw materials:

6-(benzyloxy)-7-methoxy-3,4-dihydroisoquinoline

(2R,3R,11bR)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2,9-diol

6-<5-β-(N-methyl-N-trifluoroacetylamino)ethyl-2-methoxy>phenyloxyveratric acid

6-<5-β-(N-methyl-N-trifluoroacetylamino)ethyl-2-methoxy>phenyloxyveratraldehyde