1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione
• CAS No.: 458150-94-2
• Molecular Formula: C₂₁H₁₅NO₅
• Molecular Weight: 361.354
• Mol file: 458150-94-2.mol

Synonyms:1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Chemical Property of 1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione

There total 1 articles about 1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + 2,3-diphenylmaleic anhydride (4808-48-4) → 1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione (458150-94-2)

Guidance literature:

L-glutamic acid; 2,3-diphenylmaleic anhydride; With pyridine; Reflux;

With acetic anhydride; for 0.5h; Reflux;

DOI:10.1016/j.ejmech.2009.03.018

Reference yield: 88.0%

1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione (458150-94-2) + N,N-dimethylethylenediamine (108-00-9) → 2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N,N-dimethylethanamine hydrochloride (458151-58-1)

Guidance literature:

1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione; N,N-dimethylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With acetic anhydride; acetyl chloride; for 2.5h; Reflux;

DOI:10.1016/j.ejmech.2009.03.018

Reference yield: 75.0%

1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione (458150-94-2) → 5-amino-2-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-5-oxopentanoic acid (458151-16-1)

Guidance literature:

1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione; With ammonia; In 1,4-dioxane; at 20 ℃; for 1.5h;

With hydrogenchloride; In 1,4-dioxane; water; pH=1;

DOI:10.1016/j.ejmech.2009.03.018

upstream raw materials:

L-glutamic acid

2,3-diphenylmaleic anhydride

Downstream raw materials:

5-amino-2-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-5-oxopentanoic acid

2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N-(2-(3-(2,5-dioxo-3,4-diphenyl 2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)ethyl)-N-methylethanamine hydrochloride

2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N,N-dimethylethanamine hydrochloride