5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

Base Information

Chemical Name:5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile
CAS No.:1334608-18-2
Molecular Formula:C₂₆H₂₇N₃O
Molecular Weight:397.52
Hs Code.:

Synonyms:5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

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Chemical Property of 5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

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Technology Process of 5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

There total 8 articles about 5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334608-10-4
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

: 4009-98-7
(methoxymethyl)triphenylphosphonium chloride

: 1334608-18-2
5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

Guidance literature:: (methoxymethyl)triphenylphosphonium chloride; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;

5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile; In tetrahydrofuran; at -78 ℃;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 134604-07-2
2-bromo-5-nitrobenzonitrile

: 1334608-18-2
5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 16 h / 100 °C / Inert atmosphere

2.1: zinc; water; ammonium formate / methanol / 4 h / 80 °C

3.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

6.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 - 20 °C

6.2: -78 °C

With potassium phosphate; n-butyllithium; water; hydrogen bromide; ammonium formate; potassium acetate; caesium carbonate; zinc; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene; acetonitrile;

Reference yield:

: 288251-97-8
5-amino-2-(2-methylpropyl)benzonitrile

: 1334608-18-2
5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 - 20 °C

4.2: -78 °C

With potassium phosphate; n-butyllithium; hydrogen bromide; potassium acetate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; acetonitrile;